Holwell Road will be closed for overnight roadworks, 7pm until 7am, from Monday 26 October until Friday 30 October.
The road will be closed from Holwell Road roundabout to Bandstand roundabout.
It will also be closed from Saturday 31 October until 6am on Monday 2 November.
Signed diversion routes via West Carr Lane and Leeds Road / Sutton Road to the south, and Holwell Road and Barnstaple Road to the north, will be in place.
The essential improvement works are part of the Stoneferry Corridor Works.