Essential roadworks will take place in Endike Lane from Monday 17 February to Sunday 5 April.
The work take place in two phases and road closures will be in place.
During phase one, the road will be closed between Willowfield and Freetown Court. During phase two, the closure will be in place from Freetown Court to Cranbrook Avenue roundabout.
A diversion route will be in place via Greenwood Avenue and Inglemire Lane.
Councillor Anita Harrison, portfolio holder for highways at Hull City Council, said: “We are undertaking the work in two phases so that we can try and minimise disruption to traffic.
“However this work is necessary. We apologise for the delay and ask that motorists are patient while we carry out these essential repairs.”
There will be no bus services on Endike Lane between the Cranbrook Avenue roundabout and Ellerburn Avenue. Signposts will be in place directing bus users to the nearest bus stop.
Access will be maintained for pedestrians and emergency services.