Essential roadworks are to take place in Thomas Clarkson Way from Monday 9 December to Wednesday 11 December.
The resurfacing works will take place from 7pm to 5am for three evenings next week.
The road will be closed in both directions for the duration of the works and traffic will be diverted via Ennerdale, Bude Road and John Newton Way.
Councillor Anita Harrison, portfolio holder for highways, said: “To minimise disruption, we are carrying out overnight works. However, to allow the repairs to take place safely, some traffic management will be in place.
“We apologise in advance and ask that motorists are patient while we carry out these essential repairs.”